Excerpts from a release from the International Medical Research Council (MRC):

A routine treatment for head injury may do more harm than good

A major international Medical Research Council (MRC) trial has found that a routine treatment for patients with head injuries, widely used around the world for the last 30 years, does not improve survival rates and may do more harm than good. The results of the study are published in full in one of the editions of 'The Lancet'.

Every year millions of people world-wide are treated for serious head injury. One in five die and a substantial proportion are permanently disabled. Previous studies suggested that giving patients anti-inflammatory treatments called corticosteroids, could reduce deaths by preventing the potentially lethal brain swelling that occurs after head injury. But these studies were too small to be able to provide definitive evidence of benefit...

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Raised intra cranial pressure and management - By Dr P.V. Ramana

Modern Thinking about ICP by George Kellie & Alexander Monro, Worked in Edinburgh, Beginning of 19th century Monro-Kellie hypothesis:

• Sum of intra cranial volumes of blood, brain, CSF, & other components (tumor, haematoma) is constant, and that an increase in any one of these must be offset by an equal decrease in another, or else pressure will rise.

• These volumes are contained in an inelastic, completely closed skull.

• Pressure is distributed evenly through out intra cranial compartment.

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